Potential of Indonesian Herbal Medicine, Phaleria Macrocarpa (Scheff.) Boerl, for Targeting Multiple Malignancy Signaling Pathways: An Introductory Overview
Key notes
It is
popular among Indonesians due to its wide array
of medicinal properties. In vitro and in vivo
studies have demonstrated that the fruits and
leaves extracts of MaDe to have antihyperlipidemic
[5], anti-hyperglicemic [6,7], antioxidant
[8], anti-inflammatory [9,10], antibacterial
and -fungal [11], and antiartheroscleritic
effects [12]. Moreover, its potency
as an anticancer agent has been known for
generations. Many studies have been conducted
about the extraction, isolation, and
characterization of MaDe’s bioactive constituents
(compounds) as potential sources of anticancer
agents [13-16].
Mahkota Dewa, is a medicinal plant used as an
alternative therapy in cases of advanced cancer
in Indonesia [17].
Several bioactive compounds isolated from
MaDe have been tested for their potential as
anticancer agents against several cancer cell
lines.
Based on the findings of the study,
it is reasonable to conclude that MaDe has
cancer chemoprevention potential, and can be
considered as an alternative cancer therapy.
Furthermore, the possibility of combining it with
conventional anticancer drugs might contribute to
the improvement of clinical outcomes in cancer
therapy.
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