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Potential of Indonesian Herbal Medicine, Phaleria Macrocarpa (Scheff.) Boerl, for Targeting Multiple Malignancy Signaling Pathways: An Introductory Overview

Key notes

  • It is popular among Indonesians due to its wide array of medicinal properties. In vitro and in vivo studies have demonstrated that the fruits and leaves extracts of MaDe to have antihyperlipidemic [5], anti-hyperglicemic [6,7], antioxidant [8], anti-inflammatory [9,10], antibacterial and -fungal [11], and antiartheroscleritic effects [12]. Moreover, its potency as an anticancer agent has been known for generations. Many studies have been conducted about the extraction, isolation, and characterization of MaDe’s bioactive constituents (compounds) as potential sources of anticancer agents [13-16].
  • Mahkota Dewa, is a medicinal plant used as an alternative therapy in cases of advanced cancer in Indonesia [17].
  • Several bioactive compounds isolated from MaDe have been tested for their potential as anticancer agents against several cancer cell lines.
  • Based on the findings of the study, it is reasonable to conclude that MaDe has cancer chemoprevention potential, and can be considered as an alternative cancer therapy.
  • Furthermore, the possibility of combining it with conventional anticancer drugs might contribute to the improvement of clinical outcomes in cancer therapy.
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